20 Facts about Yale Posted on August 1, 2015November 7, 2026 by TFE Times Yale researchers may have discovered the true root cause of depression: Not too little serotonin, but rather too much of another neurotransmitter called acetylcholine. A secondary effect of SSRIs is they reduce acetylcholine, which may explain their antidepressant effects Related Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20